An Update on Transfusion Related Immunomodulation (TRIM) in a Time of COVID- 19 Pandemic

Recipients' immune systems are triggered by blood and component therapy. Transfusion-related immunomodulation (TRIM) is a complicated immunological response to transfusion that results in immunosuppression. The mechanisms of TRIM include the presence residual white cells apoptotic cells, infusion immunosuppressive cytokines present donor components or occur during processing, transfer metabolically active growth factor-loaded particles extracellular vesicles, hemoglobin vesicles binds hemoglobin. variables donor-specific factors processing variables. can explain, at least partially, controversial negative clinical observed patients with covid19. Many potential treatment methods have been used practice, including supportive interventions, immunomodulators, antiviral therapy, convalescent plasma. Here, we summarize current treatments for COVID-19 infection-related diseases discuss value transfusion-related technologies regulation.